THE MOLECULAR IMPASSE OF EVOLUTION
Left-handed Proteins
Let us now examine in detail why the evolutionist scenario regarding
the formation of proteins is impossible.
Even the correct sequence of the right amino acids is still not
enough for the formation of a functional protein molecule. In addition
to these requirements, each of the 20 different types of amino acids
present in the composition of proteins must be left-handed. There
are two different types of amino acids-as of all organic molecules-called
"left-handed" and "right-handed". The difference between them is
the mirror-symmetry between their three dimensional structures,
which is similar to that of a person's right and left hands.
Amino acids of either of these two types can easily bond with one
another. But one astonishing fact that has been revealed by research
is that all the proteins in plants and animals on this planet, from
the simplest organism to the most complex, are made up of left-handed
amino acids. If even a single right-handed amino acid gets attached
to the structure of a protein, the protein is rendered useless.
In a series of experiments, surprisingly, bacteria that were exposed
to right-handed amino acids immediately destroyed them. In some
cases, they produced usable left-handed amino acids from the fractured
components.
Let us for an instant suppose that life came about by chance as
evolutionists claim it did. In this case, the right- and left-handed
amino acids that were generated by chance should be present in roughly
equal proportions in nature. Therefore, all living things should
have both right- and left-handed amino acids in their constitution,
because chemically it is possible for amino acids of both types
to combine with each other. However, as we know, in the real world
the proteins existing in all living organisms are made up only of
left-handed amino acids.
The question of how proteins can pick out only the left-handed
ones from among all amino acids, and how not even a single right-handed
amino acid gets involved in the life process, is a problem that
still baffles evolutionists. Such a specific and conscious selection
constitutes one of the greatest impasses facing the theory of evolution.
Moreover, this characteristic of proteins makes the problem facing
evolutionists with respect to "coincidence" even worse. In order
for a "meaningful" protein to be generated, it is not enough for
the amino acids to be present in a particular number and sequence,
and to be combined together in the right three-dimensional design.
Additionally, all these amino acids have to be left-handed: not
even one of them can be right-handed. Yet there is no natural selection
mechanism which can identify that a right-handed amino acid has
been added to the sequence and recognise that it must therefore
be removed from the chain. This situation once more eliminates for
good the possibility of coincidence and chance.
The Brittanica Science Encyclopaedia, which
is an outspoken defender of evolution, states that the amino acids
of all the living organisms on earth, and the building blocks of
complex polymers such as proteins, have the same left-handed asymmetry.
It adds that this is tantamount to tossing a coin a million times
and always getting heads. The same encyclopaedia states that it
is impossible to understand why molecules become left-handed or
right-handed, and that this choice is fascinatingly related to the
origin of life on earth.113
If a coin always turns up heads when tossed a million times, is
it more logical to attribute that to chance, or else to accept that
there is conscious intervention going on? The answer should be obvious.
However, obvious though it may be, evolutionists still take refuge
in coincidence, simply because they do not want to accept the existence
of "conscious intervention".
A situation similar to the left-handedness of amino acids also
exists with respect to nucleotides, the smallest units of the nucleic
acids, DNA and RNA. In contrast to proteins, in which only left-handed
amino acids are chosen, in the case of the nucleic acids, the preferred
forms of their nucleotide components are always right-handed. This
is another fact that can never be explained by coincidence.
In conclusion, it is proven beyond a shadow of doubt by the probabilities
we have examined that the origin of life cannot be explained by
chance. If we attempt to calculate the probability of an average-sized
protein consisting of 400 amino acids being selected only from left-handed
amino acids, we come up with a probability of 1 in 2400, or 10120.
Just for a comparison, let us remember that the number of electrons
in the universe is estimated at 1079, which although vast, is a
much smaller number. The probability of these amino acids forming
the required sequence and functional form would generate much larger
numbers. If we add these probabilities to each other, and if we
go on to work out the probabilities of even higher numbers and types
of proteins, the calculations become inconceivable.
Correct Bond is Vital
The difficulties the theory of evolution is unable to overcome
with regard to the development of a single protein are not limited
to those we have recounted so far. It is not enough for amino acids
to be arranged in the correct numbers, sequences, and required three-dimensional
structures. The formation of a protein also requires that amino
acid molecules with more than one arm be linked to each other only
in certain ways. Such a bond is called a "peptide bond". Amino acids
can make different bonds with each other; but proteins are made
up of those-and only those-amino acids which are joined by "peptide"
bonds.
A comparison will clarify this point. Suppose that all the parts
of a car were complete and correctly assembled, with the sole exception
that one of the wheels was fastened in place not with the usual
nuts and bolts, but with a piece of wire, in such a way that its
hub faced the ground. It would be impossible for such a car to move
even the shortest distance, no matter how complex its technology
or how powerful its engine. At first glance, everything would seem
to be in the right place, but the faulty attachment of even one
wheel would make the entire car useless. In the same way, in a protein
molecule the joining of even one amino acid to another with a bond
other than a peptide bond would make the entire molecule useless.
Research has shown that amino acids combining at random combine
with a peptide bond only 50% of the time, and that the rest of the
time different bonds that are not present in proteins emerge. To
function properly, each amino acid making up a protein must be joined
to others only with a peptide bond, in the same way that it likewise
must be chosen only from among left-handed forms.
This probability of this happening is the same as the probability
of each protein's being left-handed. That is, when we consider a
protein made up of 400 amino acids, the probability of all amino
acids combining among themselves with only peptide bonds is 1 in
2399.
Zero Probability
As can be seen below, the probability of formation of a protein
molecule made up of 500 amino acids is "1" over a number formed
by placing 950 zeros next to 1, which is a number incomprehensible
for the human mind. This is a probability only on paper. Practically
speaking, there is zero chance of its actually happening. As we
saw earlier, in mathematics, a probability smaller than 1 in 1050
is statistically considered to have a "0" probability of occurring.
A probability of "1 over 10950" is far beyond the limits
of this definition.
While the improbability of the formation of a protein molecule
made up of 500 amino acids reaches such an extent, we can further
proceed to push the limits of the mind with higher levels of improbability.
In the "haemoglobin" molecule, which is a vital protein, there are
574 amino acids, which is more than the amino acids making up the
protein mentioned above. Now consider this: in only one out of the
billions of red blood cells in your body, there are "280,000,000"
(280 million) haemoglobin molecules.
The supposed age of the earth is not sufficient to allow the formation
of even a single protein by a "trial and error" method, let alone
that of a red blood cell. Even if we suppose that amino acids have
combined and decomposed by a "trial and error" method without losing
any time since the formation of the earth, in order to form a single
protein molecule, the time that would be required for something
with a probability of 10950 to happen would still hugely exceed
the estimated age of the earth.
The conclusion to be drawn from all this is that evolution falls
into a terrible abyss of improbability even when it comes to the
formation of a single protein.
Is There a Trial and Error Mechanism in Nature?
Finally, we
may conclude with a very important point in relation to the basic
logic of probability calculations, of which we have already seen
some examples. We indicated that the probability calculations made
above reach astronomical levels, and that these astronomical odds
have no chance of actually happening. However, there is a much more
important and damaging fact facing evolutionists here. This is that
under natural conditions, no period of trial and error can even
start, despite the astronomical odds, because there is no trial-and-error
mechanism in nature from which proteins could emerge.
The calculations we give on page across to demonstrate the probability
of the formation of a protein molecule with 500 amino acids are
valid only for an ideal trial-and-error environment, which does
not actually exist in real life. That is, the probability of obtaining
a useful protein is "1" in 10950 only if we suppose that
there exists an imaginary mechanism in which an invisible hand joins
500 amino acids at random and then, seeing that this is not the
right combination, disentangles them one by one, and arranges them
again in a different order, and so on. In each trial, the amino
acids would have to be separated one by one, and be arranged in
a new order. The synthesis should be stopped after the 500th amino
acid has been added, and it must be ensured that not even one extra
amino acid is involved. The trial should then be stopped to see
whether or not a functional protein has yet been formed, and, in
the event of failure, everything should be split up again and then
tested for another sequence. Additionally, in each trial, not even
one extraneous substance should be allowed to become involved. It
is also imperative that the chain formed during the trial should
not be separated and destroyed before reaching the 499th link. These
conditions mean that the probabilities we have mentioned above can
only operate in a controlled environment where there is a conscious
mechanism directing the beginning, the end, and each intermediate
stage of the process, and where only "the correct selection of the
amino acids" is left uncontrolled. It is clearly impossible for
such an environment to exist under natural conditions. Therefore
the formation of a protein in the natural environment is logically
and technically impossible. In fact, to talk of the probabilities
of such an event is quite unscientific.
|
Zero
Probability
|
| There are 3 basic conditions for the formation
of a useful protein: First
condition: that all the amino acids
in the protein chain are of the right type and in the right
sequence
Second condition:
that all the amino acids in the chain are left-handed
Third condition: that
all of these amino acids are united between them by forming
a chemical bond called "peptide bond".
In order for a protein to be formed by chance,
all three basic conditions must exist simultaneously. The
probability of the formation of a protein by chance is equal
to the multiplication of the probabilities of the realisation
of each of these conditions.
For instance, for an average molecule comprising
of 500 amino acids:
1. The probability of the
amino acids being in the right sequence:
There are 20 types of amino acids used in the
composition of proteins. According to this:
| -The probability of each amino
acid being chosen correctly among these 20 types |
= 1/20 |
| -The probability of all of those
500 amino acids being chosen correctly |
= 1/20500= 1/10650 |
| |
= 1 chance in 10650 |
2. The probability of the
amino acids being left-handed:
| -The probability of only one
amino acid being left-handed |
= 1/2 |
| -The probability of all of
those 500 amino acids being left-handed at the same
time |
= 1/2500
= 1/10150 |
|
= 1 chance in 10150 |
3. The probability of the
amino acids being combined with a "peptide bond":
Amino acids can combine with each other with
different kinds of chemical bonds. In order for a useful protein
to be formed, all the amino acids in the chain must have been
combined with a special chemical bond called a "peptide bond".
It is calculated that the probability of the amino acids being
combined not with another chemical bond but by a peptide bond
is 50%. In relation to this:
| -The probability of two amino
acids being combined with a "peptide bond" |
= 1/2 |
| -The probability of 500 amino
acids all combining with peptide bonds |
= 1/2499
= 1/10150 |
| |
= 1 chance in 10150 |
|
|
| TOTAL PROBABILITY |
= 1/10650 X 1/10150
X 1/10150 = 10950 |
|
= 1 chance in 10950 |
|
|
|
|
The probability of an
average protein molecule made up of 500 amino acids
being arranged in the correct quantity and sequence
in addition to the probability of all of the amino
acids it contains being only left-handed and being
combined with only peptide bonds is "1" over 10950.
We can write this number which is formed by putting
950 zeros next to 1 as follows:
10950 =
100.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.
000.000.000.000.000.000.000.000.000.000.000.000.000.
|
|
Since some people are unable to take a broad view of these matters,
but approach them from a superficial viewpoint and assume protein
formation to be a simple chemical reaction, they may make unrealistic
deductions such as "amino acids combine by way of reaction
and then form proteins". However, accidental chemical reactions
taking place in an inanimate structure can only lead to simple
and primitive changes. The number of these is predetermined and
limited. For a somewhat more complex chemical material, huge factories,
chemical plants, and laboratories have to be involved. Medicines
and many other chemical materials that we use in our daily life
are made in just this way. Proteins have much more complex structures
than these chemicals produced by industry. Therefore, it is impossible
for proteins, each of which is a wonder of creation, in which every
part takes its place in a fixed order, to originate as a result
of haphazard chemical reactions.
Let us for a minute put aside all the impossibilities we have described
so far, and suppose that a useful protein molecule still evolved
spontaneously "by accident". Even so, evolution again has no answers,
because in order for this protein to survive, it would need to be
isolated from its natural habitat and be protected under very special
conditions. Otherwise, it would either disintegrate from exposure
to natural conditions on earth, or else join with other acids, amino
acids, or chemical compounds, thereby losing its particular properties
and turning into a totally different and useless substance.
  
113
Fabbri Britannica Bilim Ansiklopedisi (Fabbri Britannica Science
Encyclopaedia), vol 2, No 22, p. 519.
|